48P Macrophage-derived exosomal microRNAs regulate macrophage-cancer communications
نویسندگان
چکیده
منابع مشابه
Manipulating microRNAs to regulate macrophage polarization in gliomas.
Tumor associated macrophages (TAMs) play a critical role in solid tumor development where they regulate neoplastic cell proliferation , survival and invasion, promote angiogenesis, and impact effector functions of T cells (1). Typically, TAMs activated by toll-like receptor (TLR) signaling or interferon (IFN)-γ are considered classically activated or Th1-type cells, whereas those activated by i...
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BACKGROUND Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated macrophages (TAMs) play an important role in chemoresistance of cancer. As the important mediators in intercellular communications, exosomes secreted by ho...
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Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection of the signals which influence tumor progression is needed. Cancer stroma plays a critical role in tumor proliferation, invasion and chemoresistance. Here, we sought to identify and characterize exosomal microRNAs as mediators of stromal-t...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2020
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2020.08.200